What is Crohn’s disease?
Crohn’s disease (CD) is a chronic (long-term) inflammatory condition affecting the lining of the digestive system.1
Although any part of the gastrointestinal tract (GI) can be affected, from the mouth to the anus, Crohn’s disease most commonly occurs in the colon (the large intestine) or the last part of the small intestine (the ileum).1 The inflammation can penetrate the thick lining of the bowel wall and may occur in patches, affecting some areas but not others.2
Symptoms of Crohn’s disease
The way Crohn's disease affects different people is highly individual, and changes over time. Long periods of remission, where you have few symptoms or no symptoms at all, are punctuated by 'flare-ups' or relapses, when symptoms become active.1
The most prominent and common symptoms that most people experience at one time or another are:2,3
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Types of Crohn’s disease
Crohn’s disease can affect any part of the digestive system and this can affect the symptoms you experience and the possible treatments that are offered to you.2,3
You might have a type that affects just one area, or a combination of locations may be affected.
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In severe Crohn’s disease, patients can develop a narrowing in the bowel (a stricture) which may require surgery.2
In some rare cases, serious complications can occur, such as a perforation or rupture of the bowel (around 2 in 100 people with Crohn’s), which allows the contents of the bowel to leak through the bowel wall. A leak that goes on to form an abscess is a medical emergency, and you should see a doctor as soon as possible.3
Outside the gut
Complications of CD that affect areas outside the digestive tract are sometimes called ‘extraintestinal’ symptoms, such as:1,2
- Bones can become thinner and weaker
- Skin may become inflamed
- Eyes may become inflamed
- Liver, lungs or other organs: complications can include kidney stones, gall stones, blood clots, hair loss, and anaemia
Always mention any new or changing symptoms you have to your doctor – even if they are not related to CD they should be addressed if they affect your quality of life.
Management, treatment and monitoring
If you have been diagnosed with Crohn’s disease or ulcerative colitis you might want to find out about:
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The emotional and mental impact of IBD can be considerable, yet may not be addressed in healthcare consultations5*
– IBDrelief IBD Quality of Life Survey
Patient advocacy groups
You can find out more about inflammatory bowel disease from these independent organisations.
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*IBDrelief patient survey data from 167 respondents with IBD in the UK. 58% of respondents who did not discuss emotional wellbeing with their consultant gave a lack of time as the reason.5
Abbreviations
CD = Crohn’s disease; IBD = inflammatory bowel disease; UC = ulcerative colitis.
References
- NHS Inform. Crohn’s disease. www.nhsinform.scot/search?q=crohns&locpt=55.378051%2C-3.435973&ds=&tab=inform. Accessed October 2023.
- CCUK. Crohn’s Disease. https://crohnsandcolitis.org.uk/info-support/information-about-crohns-and-colitis/all-information-about-crohns-and-colitis/understanding-crohns-and-colitis/crohns-disease. Accessed October 2023.
- Roda G, et al. Crohn’s disease. Nat Rev Dis Primers. 2020;6(1):1-9.
- Peyrin-Biroulet L, et al. Long-term complications, extraintestinal manifestations, and mortality in adult Crohn's disease in population-based cohorts. Inflamm Bowel Dis. 2011;17(1):471-8.
- IBDrelief. Impact of IBD on physical and emotional health: Findings from an IBDrelief survey. Available at https://www.ibdrelief.com/impact-of-ibd-on-physical-and-emotional-health. Accessed October 2023.
